Diclofenac Sodium Topical Gel (DSG) 1 Reduces Swelling and Tenderness and Improves Ankle Joint Function in Subjects with Acute Ankle Sprain: A Randomized Double-Blind Placebo-Controlled Trial

摘要

Objectives:Ankle sprains are among the most common sports-related injuries and are often self-treated. Over-the-counter treatment options known to reduce pain and inflammation, such as oral non-steroidal anti-inflammatory drugs (NSAIDs), may be associated with systemic side effects (e.g. gastrointestinal), while topically applied rubefacients are frequently ineffective, despite their popularity. DSG 1%, which has been clinically proven to be effective and well-tolerated for the treatment of osteoarthritis, could be a new option for the treatment of acute injuries, such as ankle sprains. This study evaluated the efficacy and safety of DSG 1% applied q.i.d in subjects with acute ankle sprain.