Real-time Closed-loop Control in a Rodent Model of Medically-induced Coma Using Burst Suppression

摘要

BackgroundA medically-induced coma is an anesthetic state of profound brain inactivation created to treat status epilepticus and to provide cerebral protection following traumatic brain injuries. We hypothesized that a closed-loop anesthetic delivery system could automatically and precisely control the electroencephalogram state of burst suppression and efficiently maintain a medically-induced coma.