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Inhaled corticosteroid treatment modulates ZNF432 gene variantseffect on bronchodilator response in asthmatics

机译：吸入糖皮质激素治疗可调节ZNF432基因变异对哮喘患者支气管扩张剂反应的影响

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BackgroundSingle nucleotide polymorphisms (SNPs) influence a patient's response to inhaled corticosteroids and β2-agonists, and the effect of treatment with inhaled corticosteroids is synergistic with the effect of β2-agonists. We hypothesized that use of inhaled corticosteroids could influence the effect of SNPs associated with bronchodilator response.

机译：背景单核苷酸多态性（SNPs）影响患者对吸入皮质类固醇和β2激动剂的反应，吸入皮质类固醇的治疗效果与β2激动剂的效果具有协同作用。我们假设吸入皮质类固醇的吸入可能会影响与支气管扩张药反应相关的SNP的作用。

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期刊名称 other
作者
Ann C. Wu; Blanca E. Himes; Jessica Lasky-Su; Augusto Litonjua; Stephen P. Peters; John Lima; Michiaki Kubo; Mayumi Tamari; Yusuke Nakamura; Weiliang Qiu; Scott T. Weiss; Kelan Tantisira;
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年(卷),期 -1(133),3
年度 -1
页码 e3
总页数 14
原文格式 PDF
正文语种
中图分类
关键词
asthma bronchodilator response lung function inhaled corticosteroids single nucleotide polymorphisms zinc finger proteins ZNF432;

机译：哮喘;支气管扩张剂反应;肺功能;吸入性糖皮质激素;单核苷酸多态性;锌指蛋白;ZNF432;

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专利

1. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics [J] . WuA.C., HimesB.E., Lasky-SuJ., The Journal of Allergy and Clinical Immunology . 2014,第3期

机译：吸入的皮质类固醇治疗调节ZNF432基因变体对哮喘的支气管扩张剂反应的影响
2. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics [J] . WuA.C., HimesB.E., Lasky-SuJ., The Journal of Allergy and Clinical Immunology . 2014,第3期

机译：吸入糖皮质激素治疗可调节ZNF432基因变异对哮喘患者支气管扩张剂反应的影响
3. The Bronchodilator Response as a Predictor of Inhaled Corticosteroid Responsiveness in Asthmatic Children With Normal Baseline Spirometry [J] . Galant Stanley P., Morphew Tricia, Guijon Olga, Pediatric Pulmonology . 2014,第12期

机译：基线肺活量正常的哮喘儿童支气管扩张剂反应作为吸入性糖皮质激素反应的预测因子
4. Systemic Corticosteroid Treatment Reduces Bronchial Mucosal Activation of Activator Protein-1 (AP-1) Components In Cortlcosterold Sensitive, but Not Resistant Asthmatics [C] . T.-K. Loke, K.H. Mallett, J. Ratoff, Collegium Internationale Allergologicum . 2007

机译：系统皮质类固醇处理可降低Cortlcosterollold敏感的活化剂蛋白-1（AP-1）组分的支气管粘膜活化，但不能抵抗哮喘
5. Validation of a metered -dose inhaler adherence scale with an electronic medication monitor and inhaled corticosteroid adherence and concomitant bronchodilator use in adults [D] . Schiller, Kathleen Weeks 2001

机译：使用电子药物监护仪验证吸入式计量吸入器依从性量表，以及成人吸入皮质类固醇依从性和同时使用支气管扩张剂
6. Effect of allergic phenotype on treatment response to inhaled bronchodilators with or without inhaled corticosteroids in patients with COPD [O] . Shih-Lung Cheng, Hsu Hui Wang, Ching-Hsiung Lin 2017

机译：过敏表型对COPD患者吸入或吸入糖皮质激素对支气管扩张剂治疗反应的影响
7. Early response to inhaled bronchodilators and corticosteroids as a predictor of 12-month treatment responder status and COPD exacerbations [O] . Calverley, Peter M., Postma, Dirkje S., Anzueto, Antonio R., 2016

机译：吸入支气管扩张剂和皮质类固醇的早期反应可预测12个月的治疗反应者状态和COPD恶化
8. Genetic Variants in Serotonin and Corticosteroid Systems Modulate Neuroendocrine and Cardiovascular Responses to Intense Stress. [R] . Taylor, M. K., Larson, G. E., Hiller-Lauby, M. D. 2014

机译：5-羟色胺和皮质类固醇系统的遗传变异调节神经内分泌和心血管对强烈应激的反应。

Inhaled corticosteroid treatment modulates ZNF432 gene variantseffect on bronchodilator response in asthmatics

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