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The Advantage of Arriving First: Characteristic Times in Finite Size Populations of Error-Prone Replicators

机译:先到达的优势:有限错误复制器的有限大小种群中的特征时间

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摘要

We study the evolution of a finite size population formed by mutationally isolated lineages of error-prone replicators in a two-peak fitness landscape. Computer simulations are performed to gain a stochastic description of the system dynamics. More specifically, for different population sizes, we compute the probability of each lineage being selected in terms of their mutation rates and the amplification factors of the fittest phenotypes. We interpret the results as the compromise between the characteristic time a lineage takes to reach its fittest phenotype by crossing the neutral valley and the selective value of the sequences that form the lineages. A main conclusion is drawn: for finite population sizes, the survival probability of the lineage that arrives first to the fittest phenotype rises significantly.
机译:我们研究了由易错复制子的突变孤立世系在两个峰值的健身环境中突变形成的有限大小种群的进化。执行计算机仿真以获得系统动力学的随机描述。更具体地说,对于不同的种群规模,我们根据突变率和最适表型的扩增因子来计算选择每个谱系的概率。我们将结果解释为血统通过跨过中性谷而达到其最适表型所需的特征时间与形成血统的序列的选择性值之间的折衷。得出一个主要结论:对于有限的种群规模,最先到达最适表型的谱系的存活概率显着提高。

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