Kcne2 Deletion Creates a Multisystem Syndrome Predisposing to Sudden Cardiac Death

摘要

BackgroundSudden cardiac death (SCD) is the leading global cause of mortality, exhibiting increased incidence in diabetics. Ion channel gene perturbations provide a well-established ventricular arrhythmogenic substrate for SCD. However, most arrhythmia susceptibility genes - including the KCNE2 K⁺ channel β subunit - are expressed in multiple tissues, suggesting potential multiplex SCD substrates.