GABA System Genes – No Evidence for a Role in Alcohol Use and Abuse in a Community-based Sample

摘要

BackgroundWhile twin and adoption studies point to substantial genetic influence upon alcohol use, dependence, and other alcohol-related phenotypes, few of the genes underlying variation in these phenotypes have been identified. Markers in genes related to GABAergic activity—a system integral to many of alcohol’s biological effects—have been implicated in alcohol use and alcohol-related psychopathology in linkage and association studies.