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Estimating Brain Network Activity through Back-Projection of ICA Components to GLM Maps

机译:通过将ICA组件反向投影到GLM映射来估计脑网络活动

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摘要

Independent component analysis (ICA) is a data-driven approach frequently used in neuroimaging to model functional brain networks. Despite ICA’s increasing popularity, methods for replicating published ICA components across independent datasets have been underemphasized. Traditionally, the task-dependent activation of a component is evaluated by first back-projecting the component to a functional MRI (fMRI) dataset, then performing general linear modeling (GLM) on the resulting timecourse. We propose the alternative approach of back-projecting the component directly to univariate GLM results. Using a sample of 37 participants performing the Multi-Source Interference Task, we demonstrate these two approaches to yield identical results. Furthermore, while replicating an ICA component requires back-projection of component beta-values (βs), components are typically depicted only by t-scores. We show that while back-projection of component βs and t-scores yielded highly correlated results (ρ=0.95), group-level statistics differed between the two methods. We conclude by stressing the importance of reporting ICA component βs so – rather than component t-scores – so that functional networks may be independently replicated across datasets.
机译:独立成分分析(ICA)是一种数据驱动的方法,经常在神经影像学中用于对功能性大脑网络进行建模。尽管ICA越来越受欢迎,但在独立数据集中复制已发布ICA组件的方法却没有得到重视。传统上,通过首先将组件反向投影到功能MRI(fMRI)数据集,然后对所得的时间过程执行通用线性建模(GLM),来评估组件的任务相关激活。我们提出了将组件直接反投影到单变量GLM结果的另一种方法。使用执行多源干扰任务的37名参与者的样本,我们演示了这两种产生相同结果的方法。此外,虽然复制ICA组件需要对组件的beta值(βs)进行反投影,但通常仅用t分数来描述组件。我们表明,虽然分量βs和t得分的反投影产生了高度相关的结果(ρ= 0.95),但两种方法的组级统计却有所不同。最后,我们着重强调了报告ICA成分βs的重要性,而不是报告成分t分数,因此功能网络可以在数据集中独立复制。

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