Pathology of SSLOW a transmissible and fatal synthetic prion protein disorder and comparison with naturally occurring classical Transmissible Spongiform Encephalopathies

摘要

AimsNaturally occurring transmissible spongiform encephalopathies (TSEs) accumulate disease specific forms of prion protein on cell membranes in association with pathognomonic lesions. We wished to determine whether synthetic prion protein disorders recapitulated these and other sub-cellular TSE specific changes.