Ethylglucuronide and Ethyl Sulfate Assays in Clinical Trials Interpretation and Limitations: Results of a Dose Ranging Alcohol Challenge Study and Two Clinical Trials

摘要

BackgroundThe ethanol metabolites, ethyl glucuronide (EtG) and ethyl sulfate (EtS) are biomarkers of recent alcohol consumption that provide objective measures of abstinence. Our goals are to better understand the impact of cutoff concentration on test interpretation, the need for measuring both metabolites, and how best to integrate test results with self-reports in clinical trials.