The impact of missing data on clinical trials: A re-analysis of a placebo controlled trial of hypericum perforatum (St Johns Wort) and sertraline in Major Depressive Disorder

摘要

Rationale and objectiveHypericum perforatum (St John’s Wort) is used to treat depression, but the effectiveness has not been established. Recent guidelines described the analysis of clinical trials with missing data, inspiring the re-analysis of this trial using proper missing data methods. The objective was to determine whether hypericum was superior to placebo in treating major depression.