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Field-Evaluation of a New Lateral Flow Assay for Detection of Cellular and Humoral Immunity against Mycobacterium leprae

机译：新的侧向流动检测对麻风分枝杆菌的细胞和体液免疫的现场评估

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BackgroundField-applicable tests detecting asymptomatic Mycobacterium leprae (M. leprae) infection or predicting progression to leprosy, are urgently required. Since the outcome of M. leprae infection is determined by cellular- and humoral immunity, we aim to develop diagnostic tests detecting pro-/anti-inflammatory and regulatory cytokines as well as antibodies against M. leprae. Previously, we developed lateral flow assays (LFA) for detection of cytokines and anti-PGL-I antibodies. Here we evaluate progress of newly developed LFAs for applications in resource-poor settings.

机译：背景技术迫切需要在现场进行的测试，以检测无症状的麻风分枝杆菌（M. leprae）感染或预测麻风病的进展。由于麻风分枝杆菌感染的结果是由细胞和体液免疫决定的，因此我们旨在开发诊断测试，以检测促炎/抗炎和调节性细胞因子以及针对麻风分枝杆菌的抗体。以前，我们开发了用于检测细胞因子和抗PGL-1抗体的侧向流动分析（LFA）。在这里，我们评估了针对资源匮乏环境中的应用开发的最新LFA的进度。

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期刊名称 PLoS Neglected Tropical Diseases
作者
Kidist Bobosha; Elisa M. Tjon Kon Fat; Susan J. F. van den Eeden; Yonas Bekele; Jolien J. van der Ploeg-van Schip; Claudia J. de Dood; Karin Dijkman; Kees L. M. C. Franken; Louis Wilson; Abraham Aseffa; John S. Spencer; Tom H. M. Ottenhoff; Paul L. A. M. Corstjens; Annemieke Geluk;
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年(卷),期 2014(8),5
年度 2014
页码 e2845
总页数 12
原文格式 PDF
正文语种
中图分类寄生动物、寄生虫学 ; 医学寄生虫学 ;
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1. Field-Evaluation of a New Lateral Flow Assay for Detection of Cellular and Humoral Immunity against Mycobacterium leprae [J] . Kidist Bobosha, Elisa M. Tjon Kon Fat, Susan J. F. van den Eeden, PLOS Neglected Tropical Diseases . 2014 ,第5期

机译：一种新的侧向流动检测法对麻风分枝杆菌的细胞和体液免疫力的现场评估
2. Lateral flow assay for simultaneous detection of cellular- and humoral immune responses. [J] . Corstjens PL, de Dood CJ, van der Ploeg van Schip JJ, Clinical Biochemistry . 2011 ,第14a15期

机译：横向血流分析可同时检测细胞和体液免疫反应。
3. Identification of Mycobacterium leprae antigens from a cosmid library: characterization of a 15-kilodalton antigen that is recognized by both the humoral and cellular immune systems in leprosy patients. [J] . S Sela, J E Thole, T H Ottenhoff, Infection and immunity . 1991 ,第11期

机译：从粘粒文库中鉴定麻风分枝杆菌抗原：麻风病人的体液和细胞免疫系统均识别的15-千达尔顿抗原的特征。
4. Portable image-based detection system for Upconverting phosphor immune lateral flow assay [C] . Chao Li, Meng Chen, Zhi Cheng, International Conference on Biological Information and Biomedical Engineering . 2019

机译：基于便携式图像的检测系统，用于上变荧光体免疫横向流动测定
5. Characterization of the humoral immune system of the Stellar sea lion, Eumetopias jubatus, and development of reagents and assays for quantitative measure of humoral immunity [D] . Colvocoresses, Jennifer Ann 2004

机译：恒星海狮Eumetopias jubatus的体液免疫系统的表征，以及用于体液免疫定量测量的试剂和测定法的发展
6. Lateral flow assay for simultaneous detection of cellular- and humoral immune responses [O] . Paul L.A.M. Corstjens, Claudia J. de Dood, Jolien J. van der Ploeg-van Schip, -1

机译：侧向流动测定用于同时检测细胞和体液免疫应答
7. Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae. [O] . Kidist Bobosha, Elisa M Tjon Kon Fat, Susan J F van den Eeden, 2014

机译：用于检测针对麻风分枝杆菌的细胞和体液免疫的新侧向流动测定的现场评估。
8. The Cellular and Humoral Immune Response to 'Schistosoma mansoni' Infections in Inbred Rats. V. Prerequisite Mechanisms for the Development of Optimal Protective Immunity. [R] . Phillips, S. M., Reid, W. A., Doughty, B., 1977

机译：近交系大鼠'曼氏血吸虫'感染的细胞和体液免疫应答。 V.开发最佳保护性免疫的先决条件机制。

Field-Evaluation of a New Lateral Flow Assay for Detection of Cellular and Humoral Immunity against Mycobacterium leprae

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