Drug Disposition Alterations in Liver Disease: Extra-hepatic Effects in Cholestasis and Nonalcoholic Steatohepatitis

摘要

IntroductionThe pharmacokinetics of drugs and xenobiotics, namely pharmaceuticals, is influenced by a host of factors that include genetics, physiological factors, and environmental stressors. The importance of disease on the disposition of xenobiotics has been increasingly recognized among medical professionals for alterations in key enzymes and membrane transporters that influence drug disposition and contribute to the development of adverse drug reactions.