White Matter Microstructural Abnormalities of the Cingulum Bundle in Youth with 22q11.2 Deletion Syndrome: Associations with Medication Neuropsychological Function and Prodromal Symptoms of Psychosis

摘要

BackgroundThe 22q11.2 Deletion Syndrome (22q11.2DS) is regarded as an etiologically homogenous model for understanding neuroanatomic disruptions associated with a high risk for schizophrenia. This study utilized diffusion tensor imaging (DTI) to analyze white matter microstructure in individuals with 22q11.2DS. We focused on the cingulum bundle (CB), previously shown to be disrupted in patients with schizophrenia and associated with symptoms of psychosis.