Automated assessment of renal cortical surface roughness from computerized tomography images and its association with age

摘要

Rationale and ObjectivesNephrosclerosis occurs with aging and is characterized by increased kidney sub-capsular surface irregularities at autopsy. Assessments of cortical roughness in-vivo could provide an important measure of nephrosclerosis. The purpose of this study was to develop and validate an image-processing algorithm for quantifying renal cortical surface roughness in-vivo and determine its association with age.