Objectives:Rotator cuff tears are a common source of shoulder pain and disability. Even after surgical repair of these tears, many patients continue to have reduced shoulder function and a progression of intramuscular fatty degeneration. Previous work in a sheep model demonstrated that a slow, progressive lengthening of chronically torn cuff muscles followed by surgical repair of the tendon reversed fatty degeneration and improved muscle function. As patients with chronic cuff tears often experience a shortening of the muscle fibers, it is possible that repairing the torn tendon to its original anatomical footprint induces a massive stretch-induced muscle injury that could contribute to poor outcomes after repair. Evans Blue Dye (EBD) is a water soluble, membrane impermeable dye, that is used to identify muscle fibers that have suffered an injury to their plasma membrane. We hypothesized that, compared with acutely torn and repaired rotator cuff muscles, the substantial stretch that is required to repair a chronically torn and shortened rotator cuff would result in significant muscle fiber damage.
展开▼
机译:目的:肩袖撕裂是肩部疼痛和残疾的常见原因。即使在对这些眼泪进行手术修复之后,许多患者仍会肩部功能下降,并出现肌肉内脂肪变性的进展。先前在绵羊模型中进行的研究表明,慢性撕裂的袖带肌肉缓慢,渐进地延长,然后进行肌腱的外科修复,可逆转脂肪变性并改善肌肉功能。由于患有慢性袖带撕裂的患者通常会经历肌肉纤维的缩短,因此将撕裂的肌腱修复至其原始的解剖结构可能会导致巨大的牵拉性肌肉损伤,从而可能导致修复后的不良结果。 Evans Blue Dye(EBD)是一种水溶性的,不透膜的染料,用于鉴定肌肉纤维质膜受损。我们假设,与急性撕裂并修复的肩袖肌肉相比,修复慢性撕裂和缩短的肩袖所需的大量拉伸会导致明显的肌纤维损伤。
展开▼