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A Combined Analysis of 48 Type 2 Diabetes Genetic Risk Variants Shows No Discriminative Value to Predict Time to First Prescription of a Glucose Lowering Drug in Danish Patients with Screen Detected Type 2 Diabetes

机译：对48种2型糖尿病遗传风险变量的综合分析显示在筛查出2型糖尿病的丹麦患者中预测降糖药物首次用药时间没有区别价值

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ObjectiveTo investigate the genetic influence of 48 type 2 diabetes susceptibility variants on disease progression measured as risk of early prescription redemption of glucose lowering drugs in screen-detected patients with type 2 diabetes.

机译：目的探讨筛查发现的2型糖尿病患者中48种2型糖尿病易感性变异对疾病进展的遗传影响，以早期处方降糖药物的风险来衡量。

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Malene Hornbak; Kristine Højgaard Allin; Majken Linnemann Jensen; Cathrine Juel Lau; Daniel Witte; Marit Eika Jørgensen; Annelli Sandbæk; Torsten Lauritzen; Åsa Andersson; Oluf Pedersen; Torben Hansen;
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年(卷),期 -1(9),8
年度 -1
页码 e104837
总页数 9
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专利

1. HbA_1c as predictor of all-cause mortality in individuals at high risk of diabetes with normal glucose tolerance, identified by screening: a follow-up study of the Anglo–Danish–Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION), Denmark [J] . M. V. Skriver, K. Borch-Johnsen, T. Lauritzen, Diabetologia . 2010,第11期

机译：通过筛查发现，HbA _{1c 可以预测糖耐量正常的高危糖尿病患者的全因死亡率，这是对盎格鲁-丹麦-荷兰人强化治疗的后续研究丹麦，在初级保健中接受筛查的糖尿病患者（ADDITION）}
2. The Evaluation of Screening and Early Detection Strategies for Type 2 Diabetes and Impaired Glucose Tolerance (DETECT-2) update of the Finnish diabetes risk score for prediction of incident type 2 diabetes [J] . M. Alssema, D. Vistisen, M. W. Heymans, Diabetologia . 2011,第5期

机译：评估2型糖尿病的筛查和早期检测策略以及糖耐量减低（DETECT-2）更新芬兰糖尿病风险评分以预测2型糖尿病的发生
3. Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores [J] . Dolores Corella, Oscar Coltell, Jose V. Sorlí, Nutrients . 2016,第12期

机译：在PREDIMED研究中，转录因子7-Like 2基因（TCF7L2）的多态性与肥胖症在2型糖尿病上的相互作用，强调2型糖尿病遗传变异的异质性风险预测：肥胖特定遗传风险评分的时间
4. Towards a mobile solution for predicting illness in Type 1 Diabetes Mellitus: Development of a prediction model for detecting risk of illness in Type 1 Diabetes prior to symptom onset [C] . Lauritzen Jonas N, Arsand Eirik, Van Vuurden Klaske, 2011 2nd International Conference on Wireless Communication, Vehicular Technology, Information Theory and Aerospace Electronic Systems Technology . 2011

机译：迈向可预测1型糖尿病疾病的移动解决方案：开发用于在症状发作之前检测1型糖尿病疾病风险的预测模型
5. Decreasing the confusion of diabetes: Focused education and management risk reduction strategies aimed at decreasing cardiovascular risk for patients with type 2 diabetes. [D] . Kimpton, Shandra Lee Ann. 2003

机译：减少糖尿病的混乱：集中的教育和管理风险降低策略旨在降低2型糖尿病患者的心血管风险。
6. Polymorphism of the Transcription Factor 7-Like 2 Gene (TCF7L2) Interacts with Obesity on Type-2 Diabetes in the PREDIMED Study Emphasizing the Heterogeneity of Genetic Variants in Type-2 Diabetes Risk Prediction: Time for Obesity-Specific Genetic Risk Scores [O] . Dolores Corella, Oscar Coltell, Jose V. Sorlí, 2016

机译：在PREDIMED研究中转录因子7样2基因（TCF7L2）的多态性与肥胖症在2型糖尿病上的相互作用强调2型糖尿病遗传变异的异质性风险预测：肥胖症特定遗传风险评分的时间
7. A combined analysis of 48 type 2 diabetes genetic risk variants shows no discriminative value to predict time to first prescription of a glucose lowering drug in Danish patients with screen detected type 2 diabetes. [O] . Malene Hornbak, Kristine Højgaard Allin, Majken Linnemann Jensen, 2014

机译：对48种2型糖尿病遗传风险变异体的联合分析显示，在筛查检测到2型糖尿病的丹麦患者中，预测首次处方葡萄糖降低药物的时间没有判别价值。

A Combined Analysis of 48 Type 2 Diabetes Genetic Risk Variants Shows No Discriminative Value to Predict Time to First Prescription of a Glucose Lowering Drug in Danish Patients with Screen Detected Type 2 Diabetes

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