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Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT

机译：姜黄素抑制肿瘤微环境中结肠癌干细胞与间质成纤维细胞之间的串扰：EMT的潜在作用

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ObjectiveInteraction of stromal and tumor cells plays a dynamic role in initiating and enhancing carcinogenesis. In this study, we investigated the crosstalk between colorectal cancer (CRC) cells with stromal fibroblasts and the anti-cancer effects of curcumin and 5-Fluorouracil (5-FU), especially on cancer stem cell (CSC) survival in a 3D-co-culture model that mimics in vivo tumor microenvironment.

机译：目的基质细胞与肿瘤细胞的相互作用在引发和增强癌变中起着动态作用。在这项研究中，我们研究了具有基质成纤维细胞的结直肠癌细胞（CRC）与姜黄素和5-氟尿嘧啶（5-FU）的抗癌作用，尤其是在3D-co中对癌症干细胞（CSC）存活的影响。 -模拟体内肿瘤微环境的培养模型。

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期刊名称 other
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Constanze Buhrmann; Patricia Kraehe; Cora Lueders; Parviz Shayan; Ajay Goel; Mehdi Shakibaei;
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年(卷),期 -1(9),9
年度 -1
页码 e107514
总页数 15
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专利

1. Curcumin inhibits pancreatic cancer cell invasion and EMT by interfering with tumor-stromal crosstalk under hypoxic conditions via the IL-6/ERK/NF-kappa B axis [J] . Oncology reports . 2020 ,第1期

机译：通过IL-6 / ERK / NF-κB轴干扰缺氧条件下的肿瘤 - 基质串扰，姜黄素抑制胰腺癌细胞侵袭和EMT
2. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFkappaB activation in the tumor stromal microenvironment. [J] . Martinez Outschoorn UE, Trimmer C, Lin Z, Cell cycle . 2010 ,第17期

机译：癌症相关的成纤维细胞中的自噬促进肿瘤细胞存活：缺氧，HIF1诱导和NFkappaB激活在肿瘤基质微环境中的作用。
3. Modeling colon adenocarcinomas in vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction. [J] . Dolznig H, Rupp C, Puri C, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2011 ,第1期

机译：在3D共培养系统中体外模拟结肠腺癌，在肿瘤细胞和基质成纤维细胞相互作用后诱导癌症相关途径。
4. An integrated microfluidic system for screening of peptides specific to colon cancer cells and colon cancer stem cells using the phage display technology [C] . Che Yu-Jui, Wu Huei-Wen, Hung Lein-Yu, IEEE International Conference on Nano/Micro Engineered and Molecular Systems . 2014

机译：使用噬菌体展示技术，用于筛选结肠癌细胞和结肠癌干细胞特异肽的集成微流系统
5. The effect of cellular and acellular components of the tumor microenvironment on both tumor and stromal cell phenotypes in a breast cancer model system [D] . McLane, Joshua 2015

机译：乳腺癌模型系统中肿瘤微环境的细胞和非细胞成分对肿瘤和基质细胞表型的影响
6. Tumor-Stroma Crosstalk in Bone Tissue: The Osteoclastogenic Potential of a Breast Cancer Cell Line in a Co-Culture System and the Role of EGFR Inhibition [O] . Laura Mercatali, Federico La Manna, Giacomo Miserocchi, 2017

机译：骨组织中的肿瘤间质串扰：乳腺癌细胞系在共同培养系统中破骨细胞的潜力和EGFR抑制的作用。
7. Curcumin suppresses crosstalk between colon cancer stem cells and stromal fibroblasts in the tumor microenvironment: potential role of EMT. [O] . Constanze Buhrmann, Patricia Kraehe, Cora Lueders, 2014

机译：姜黄素抑制肿瘤微环境中结肠癌干细胞和基质成纤维细胞之间的串扰：EmT的潜在作用。

Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT

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