Enantioselective Rh-Catalyzed Hydroacylation of Olefins: From Serendipitous Discovery to Rational Design

摘要

Rh-catalysed hydroacylation allows the construction of chiral ketones from olefins and aldehydes. Since James' and Young's serendipitous discovery of the enantioselective 4-pentenal cyclisation, both intra and intermolecular variants have emerged that enable broader applications.