Histone deacetylase 6 inhibition impairs effector CD8 T-cell functions during skin inflammation

摘要

BackgroundBroad spectrum histone deacetylase (HDAC) inhibitors are useful in the treatment of allergic and autoimmune diseases and malignancy. However, use of more specific HDAC inhibitors may limit the toxicities caused by HDAC inhibition. HDAC6, a member of the HDAC family, is highly expressed on CD8 T-cells, and it has been shown to regulate immune responses via interactions between T-cells and antigen-presenting cells; however, the mechanism by which HDAC6 inhibition affects the activation and functions of CD8 T-cell is unclear.