Differential Effects of Ethanol on Bid tBid and Bax:tBid Interactions in Postnatal Day 4 and Postnatal Day 7 Rat Cerebellum

摘要

BackgroundExposure to ethanol during central nervous system (CNS) development can lead to a wide array of neuroanatomical, behavioral and cognitive abnormalities, broadly subsumed under the Fetal Alcohol Spectrum Disorder (FASD) classification. One mode of ethanol-induced interference in the normal developmental program appears to be through induction of apoptotic processes mediated by the Bcl-2 family of survival-regulatory proteins. The present series of studies investigated the role of the Bcl-2-related, pro-apoptotic Bid protein, and its truncated, apoptotically active fragment, tBid, in developmental ethanol neurotoxicity.