General Method for Synthesis of Salicylic Acids from Phenols via Pd-Catalyzed Silanol-Directed C–H Carboxylation

摘要

A silanol directed, palladium catalyzed C–H carboxylation reaction of phenols into salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional group tolerance. The generality of this method was demonstrated by carboxylation of estrone and by the synthesis of a bis-unsymmetrically substituted phenolic compound via iterative C–H functionalizations.