The Hippo coactivator YAP1 mediates EGFR overexpression and confers chemo-resistance in esophageal cancer

摘要

PurposeEsophageal cancer (EC) is an aggressive malignancy and often resistant to therapy. Overexpression of EGFR has been associated with poor prognosis of EC patients. However, clinical trials using EGFR inhibitors have not provided benefit for EC patients. Failure of EGFR inhibition may be due to crosstalk with other oncogenic pathways.