Feeding cancer’s sweet tooth: specialized tumor vasculature shuttles glucose in Pancreatic ductal adenocarcinoma

摘要

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal neoplasm characterized by a “fortress” of thick collagen fibers, abundant myofibroblasts and paradoxically reduced vascularization compared to normal pancreas. Despite these features, PDAC shows no reduction in the uptake of glucose that fuels tumor cell survival. In new work published in The Journal of Pathology, Hexige and colleagues have identified a novel adaptation of PDAC tumor endothelium; namely, “hairy-like” basal microvilli that increase the total vascular surface area and correlate with regions of highest glucose uptake. Since basal microvilli are not present on normal pancreatic blood vessels, their presence may add diagnostic value and blocking their function is a potential new treatment strategy for PDAC. This novel finding of basal microvilli on PDAC endothelium is a striking example of how phenotypic plasticity in tumor blood vessels contributes to tumor growth and progression, independent of conventional modes of angiogenesis.