Hemoglobin-Based Oxygen Carriers Promote Systemic Hyperfibrinolysis That is Both Dependent and Independent of Plasmin

摘要

BackgroundHyperfibrinolysis plays an integral role in the genesis of trauma-induced coagulopathy (TIC). Recent data demonstrates that red blood cell (RBC) lysis promotes fibrinolysis; however, the mechanism is unclear. Hemoglobin-based oxygen carriers (HBOC) have been developed for resuscitation and have been associated with coagulopathy. We hypothesize that replacement of whole blood (WB) using an HBOC results in a coagulopathy due to the presence of free hemoglobin.