Murine fibroblastic reticular cells from lymph node interact with CD4+ T cells through CD40-CD40L

摘要

BackgroundCostimulatory blockade with anti-CD40L mAb plus donor-specific splenocyte transfusion (DST) induces alloantigen-specific tolerance. We previously showed that lymphotoxin signaling in the fibroblastic reticular cell (FRC) stromal subset was required for proper lymph node structure and function during tolerization in murine cardiac transplantation. Here we focused on FRC functions and hypothesized that donor-specific splenocyte transfusion and anti-CD40L mAb modulated FRC interactions with CD4⁺ T cells in mice.