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Pre-cART Elevation of CRP and CD4+ T-cell Immune Activation Associated with HIV Clinical Progression in a Multinational Case-Cohort Study

机译：多国病例队列研究中CRP和CD4 + T细胞免疫激活的cART升高与HIV临床进展相关

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BackgroundDespite the success of combination antiretroviral therapy (cART), a subset of HIV-infected patients who initiate cART develop early clinical progression to AIDS; therefore some cART initiators are not fully benefitted by cART. Immune activation pre-cART may predict clinical progression in cART initiators.

机译：尽管联合抗逆转录病毒疗法（cART）取得了成功，但发起cART的一部分HIV感染患者开始了早期的艾滋病临床发展；因此，某些cART启动器不能完全从cART中受益。 cART之前的免疫激活可以预测cART引发剂的临床进展。

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期刊名称 other
作者
Ashwin Balagopal; David M. Asmuth; Wei-Teng Yang; Thomas B. Campbell; Nikhil Gupte; Laura Smeaton; Cecilia Kanyama; Beatriz Grinsztejn; Breno Santos; Khuanchai Supparatpinyo; Sharlaa Badal-Faesen; Javier R. Lama; Umesh G. Lalloo; Fatima Zulu; Jyoti S Pawar; Cynthia Riviere; Nagalingeswaran Kumarasamy; James Hakim; Xiao-Dong Li; Richard B. Pollard; Richard D. Semba; David L. Thomas; Robert C. Bollinger; Amita Gupta;
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年(卷),期 -1(70),2
年度 -1
页码 163–171
总页数 20
原文格式 PDF
正文语种
中图分类
关键词
immune activation global HIV cART clinical outcomes C-Reactive protein T-cell activation;

机译：免疫激活;整体HIV;cART临床结果;C反应蛋白;T细胞激活;

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专利

1. Pre-cART Elevation of CRP and CD4(+) T-Cell Immune Activation Associated With HIV Clinical Progression in a Multinational Case-Cohort Study [J] . Balagopal Ashwin, Asmuth David M., Yang Wei-Teng, JAIDS: Journal of acquired immune deficiency syndromes . 2015,第2期

机译：在多国病例队列研究中，CRP和CD4（+）T细胞免疫激活的cART升高与HIV临床进展相关
2. Liver fibrosis progression and clinical outcomes are intertwined: role of CD4+ T-cell count and NRTI exposure from a large cohort of HIV/HCV-coinfected patients with detectable HCV-RNA: A MASTER cohort study [J] . Focà Emanuele, Fabbiani Massimiliano, Prosperi Mattia, Medicine. . 2016,第29期

机译：肝纤维化进展和临床结果是交织的：CD4 + T细胞计数的作用和NRTI从大型HIV / HCV-RNA患者中的伴有可检测HCV-RNA的患者的作用：母群队列研究
3. Characterization of CD4+ T-cell immune activation and interleukin 10 levels among HIV, hepatitis C virus, and HIV/HCV-coinfected patients [J] . HodowanecA.C., BradyK.E., GaoW., JAIDS: Journal of acquired immune deficiency syndromes . 2013,第3期

机译：HIV，丙型肝炎病毒和HIV / HCV合并感染患者中CD4 + T细胞免疫激活和白介素10水平的表征
4. Multiplexed Quantitative Proteomics of Human CD4+ T-cell Activation [C] . Robert Moulder, Tapio Lonnberg, Anne Rokka, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：人CD4 + T细胞活化的多重定量蛋白质组学
5. The role of immune activation in mediating CD4+ T cell loss in HIV disease progression [D] . Koesters, Sandra A. 2007

机译：免疫活化在HIV疾病进展中介导CD4 + T细胞丧失的作用
6. Gag-Specific CD4+ T-Cell Frequency Is Inversely Correlated with Proviral Load and Directly Correlated with Immune Activation in Infection with Human Immunodeficiency Virus Type 2 (HIV-2) but Not HIV-1 [O] . Russell B. Foxall, Catarina S. Cortesão, Adriana S. Albuquerque, 2008

机译：特定于Gag的CD4 + T细胞频率与前病毒载量呈负相关与感染人类2型免疫缺陷病毒（HIV-2）的免疫激活直接相关而与HIV-1无关。
7. Liver fibrosis progression and clinical outcomes are intertwined: Role of CD4+ T-cell count and NRTI exposure from a large cohort of HIV/HCVcoinfected patients with detectable HCV-RNA A MASTER cohort study [O] . Foca, Emanuele, Fabbiani, Massimiliano, Prosperi, Mattia, 2016

机译：肝纤维化进展和临床结局相互交织：大量可检测HCV-RNA感染HIV / HCV的患者队列中CD4 + T细胞计数和NRTI暴露的作用MASTER队列研究

Pre-cART Elevation of CRP and CD4+ T-cell Immune Activation Associated with HIV Clinical Progression in a Multinational Case-Cohort Study

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