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Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y-86- or Lu-177-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

机译：使用皮摩尔亲和力Y-86-或Lu-177-DOTA-Bn结合scFv C825 / GPA33 IgG双特异性免疫偶联物在小鼠中进行大肠癌异种移植的靶向治疗的放射疗法

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PurposeGPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pre-targeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificity for GPA33 tumor antigen and DOTA-Bn (radiolanthanide metal) complex.

机译：目的GPA33是一种大肠癌（CRC）抗原，在huA33介导的肿瘤靶向后具有独特的保留特性。我们使用针对GPA33肿瘤抗原和DOTA-Bn（放射性金刚烷金属）复合物具有双重特异性的四价双特异性抗体，对CRC的预靶向放射免疫疗法（PRIT）方法进行了测试。

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期刊名称 other
作者
Sarah M. Cheal; Hong Xu; Hong-fen Guo; Sang-gyu Lee; Blesida Punzalan; Sandhya Chalasani; Edward K. Fung; Achim Jungbluth; Pat B. Zanzonico; Jorge A. Carrasquillo; Joseph O’Donoghue; Peter M. Smith-Jones; K. Dane Wittrup; Nai-Kong V. Cheung; Steven M. Larson;
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年(卷),期 -1(43),5
年度 -1
页码 925–937
总页数 21
原文格式 PDF
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关键词
multistep targeting bispecific antibodies GPA33 radioimmunotherapy pretargeting;

机译：多步靶向;双特异性抗体;GPA33;放射免疫疗法;预靶向;

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1. Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y-86- or Lu-177-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [J] . Cheal Sarah M., Xu Hong, Guo Hong-fen, European Journal of Nuclear Medicine and Molecular Imaging . 2016,第5期

机译：使用皮摩尔亲和力Y-86-或Lu-177-DOTA-Bn结合scFv C825 / GPA33 IgG双特异性免疫偶联物在小鼠中进行大肠癌异种移植的靶向治疗的放射疗法
2. Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer [J] . Sarah M. Cheal, Edward K. Fung, Mitesh Patel, The Journal of Nuclear Medicine . 2017,第11期

机译：基于双特异性抗体预靶向策略的定量SPECT / CT为基础的治疗学监测的治疗性多周期放射免疫疗法在结直肠癌中的应用
3. Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer [J] . Cheal Sarah M., Fung Edward K., Patel Mitesh, The Journal of Nuclear Medicine . 2017,第11期

机译：定量SPECT / CT型Theranostics监测疗中多网放射免疫疗法，在结直肠癌中使用双特异性抗体预靶策略
4. Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer [O] . Sarah M. Cheal, Edward K. Fung, Mitesh Patel, -1

机译：基于双特异性抗体预靶向策略的定量SPECT / CT为基础的治疗学监测的治疗性多周期放射免疫疗法在结直肠癌中的应用
5. Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [O] . Xu Hong, Guo Hong-fen, Lee Sang-gyu, 2016

机译：使用皮摩尔亲和力86Y-或177Lu-DOTa-Bn结合scFv C825 / Gpa33 IgG双特异性免疫缀合物对小鼠结肠直肠癌异种移植物进行治疗预防性预靶向放射免疫治疗

Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y-86- or Lu-177-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

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