Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y-86- or Lu-177-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

Cheal Sarah M.; Xu Hong; Guo Hong-fen; Lee Sang-gyu; Punzalan Blesida; Chalasani Sandhya; Fung Edward K.; Jungbluth Achim; Zanzonico Pat B.; Carrasquillo Jorge A.; ODonoghue Joseph; Smith-Jones Peter M.; Wittrup K. Dane; Cheung Nai-Kong V.; Larson Steven M.

首页> 外文期刊>European Journal of Nuclear Medicine and Molecular Imaging >Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y-86- or Lu-177-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

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Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y-86- or Lu-177-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

机译：使用皮摩尔亲和力Y-86-或Lu-177-DOTA-Bn结合scFv C825 / GPA33 IgG双特异性免疫偶联物在小鼠中进行大肠癌异种移植的靶向治疗的放射疗法

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Purpose GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificity for GPA33 tumor antigen and DOTA-Bn-(radiolanthanide metal) complex.

机译：目的GPA33是在huA33介导的肿瘤靶向后具有独特保留特性的结直肠癌（CRC）抗原。我们测试了针对CRC的预靶向放射免疫疗法（PRIT）方法，该方法使用对GPA33肿瘤抗原和DOTA-Bn-（放射性金刚烷金属）复合物具有双重特异性的四价双特异性抗体。

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《European Journal of Nuclear Medicine and Molecular Imaging》 |2016年第5期|共13页
作者
Cheal Sarah M.; Xu Hong; Guo Hong-fen; Lee Sang-gyu; Punzalan Blesida; Chalasani Sandhya; Fung Edward K.; Jungbluth Achim; Zanzonico Pat B.; Carrasquillo Jorge A.; ODonoghue Joseph; Smith-Jones Peter M.; Wittrup K. Dane; Cheung Nai-Kong V.; Larson Steven M.;
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正文语种 eng
中图分类放射医学;
关键词
Multistep targeting; Bispecific antibodies; GPA33; Radioimmunotherapy; Pretargeting;

机译：多步靶向;双特异性抗体;GPA33;放射免疫疗法;预靶向;

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1. Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y-86- or Lu-177-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [J] . Cheal Sarah M., Xu Hong, Guo Hong-fen, European Journal of Nuclear Medicine and Molecular Imaging . 2016,第5期

机译：使用皮摩尔亲和力Y-86-或Lu-177-DOTA-Bn结合scFv C825 / GPA33 IgG双特异性免疫偶联物在小鼠中进行大肠癌异种移植的靶向治疗的放射疗法
2. Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer [J] . Cheal Sarah M., Fung Edward K., Patel Mitesh, The Journal of Nuclear Medicine . 2017,第11期

机译：定量SPECT / CT型Theranostics监测疗中多网放射免疫疗法，在结直肠癌中使用双特异性抗体预靶策略
3. Pretargeted radioimmunotherapy of human colorectal xenografts with bispecific antibody and 131I-labeled bivalent hapten. [J] . Gautherot E, Rouvier E, Daniel L, The Journal of Nuclear Medicine . 2000,第3期

机译：用双特异性抗体和131I标记的二价半抗原对人大肠异种移植物进行预靶向放射免疫治疗。
4. Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y-86- or Lu-177-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [O] . Sarah M. Cheal, Hong Xu, Hong-fen Guo, -1

机译：使用皮摩尔亲和力Y-86-或Lu-177-DOTA-Bn结合scFv C825 / GPA33 IgG双特异性免疫偶联物在小鼠中进行大肠癌异种移植的靶向治疗的放射疗法
5. Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [O] . Xu Hong, Guo Hong-fen, Lee Sang-gyu, 2016

机译：使用皮摩尔亲和力86Y-或177Lu-DOTa-Bn结合scFv C825 / Gpa33 IgG双特异性免疫缀合物对小鼠结肠直肠癌异种移植物进行治疗预防性预靶向放射免疫治疗

Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity Y-86- or Lu-177-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates

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