Data Extraction and Management in Networks of Observational Health Care Databases for Scientific Research: A Comparison of EU-ADR OMOP Mini-Sentinel and MATRICE Strategies

摘要

Introduction:We see increased use of existing observational data in order to achieve fast and transparent production of empirical evidence in health care research. Multiple databases are often used to increase power, to assess rare exposures or outcomes, or to study diverse populations. For privacy and sociological reasons, original data on individual subjects can’t be shared, requiring a distributed network approach where data processing is performed prior to data sharing.