Multiband Spectral-Spatial RF Excitation for Hyperpolarized 2-13CDihydroxyacetone 13C-MR Metabolism Studies

摘要

PurposeTo develop a specialized multislice, single-acquisition approach to detect the metabolites of hyperpolarized [2-¹³C]dihydroxyacetone (DHAc) to probe gluconeogenesis in vivo, which have a broad 144 ppm spectral range (~4.6 KHz at 3T). A novel multiband RF excitation pulse was designed for independent flip angle control over 5-6 spectral-spatial (SPSP) excitation bands, each corrected for chemical shift misregistration effects.