Nineteen metabolites with diverse structures, including the rare pyrroloindoline alkaloid verrupyrroloindoline (>1), the unprecedented highly fused benzosesquiterpenoid verrubenzospirolactone (>2), the new asteriscane-type sesquiterpenoid 10-deoxocapillosanane D (>3), and the two new cyclopentenone derivatives (4S*,5S*)-4-hydroxy-5-(hydroxymethyl)-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (>4) and (S)-4-hydroxy-5-methylene-2,3-dimethyl-4-pentylcyclopent-2-en-1-one (>5), were isolated from a South China Sea collection of the soft coral Sinularia verruca. Eleven previously described marine metabolites (>7–>15, >18, and >19) were also obtained as well as three new EtOH-adduct artifacts (>6, >16, and >17). The structures of the new compounds were elucidated by extensive spectroscopic analysis and by comparison with previously reported data. Compounds >4, >5, and >16 showed protection against the cytopathic effects of HIV-1 infection with EC50 values of 5.8–34 μM, and >4, >6, and >16 exhibited inhibition against LPS-induced NO production with IC50 values of 24–28 μM.
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