Effect of Formulation Parameters on the Preparation of Superporous Hydrogel Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Carvedilol

摘要

The purpose of this study was to formulate a superporous hydrogel (SPH) containing carvedilol self-nanoemulsifying drug delivery system. Effects of formulation parameters (amount of SPH and 0.1 N HCl used during drug loading) were studied in 3² factorial design. Response surface plots showed significant effect of the parameters on hydrogel swelling, carvedilol content, and carvedilol in vitro release. Regression equations were generated to calculate the desirable responses.