Incorporating Dixon Multi-Echo Fat Water Separation for Novel Quantitative Magnetization Transfer of the Human Optic Nerve in vivo

摘要

PurposeThe optic nerve (ON) represents the sole pathway between the eyes and brain; consequently, diseases of the ON can have dramatic effects on vision. However, qMT applications in the ON have been limited to ex vivo studies, in part due to the fatty connective tissue, which surrounds the ON, confounding the MT experiment. Therefore, the aim of this study was to implement a multi-echo Dixon fat-water separation approach to remove the fat component from MT images.