Gd-TEMDO: Design synthesis and MRI application

摘要

A simple Ugi tetrazole multicomponent reaction allows the synthesis of a novel macrocyclic cyclen derivative with four appendant tetrazole arms in just two steps in excellent yields. This ligand, called TEMDO, turns out to be a very good complexator of lanthanoid metals. Here we describe the design, synthesis, solid state structure, binding constant and some MRI applications of the Gd-TEMDO complex as the first example of a congeneric family of oligo-amino tetrazoles.