Senescence can be BETter without the SASP?

摘要

Global remodelling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this study, Tasdemir et al () show that the epigenetic regulator BRD4 is required for expression of the pro-inflammatory “senescence-associated secretory phenotype” (SASP) and immune clearance of senescent cells in vitro and in vivo. Their results could be useful in design of novel therapies to treat aging-related diseases, including cancer.