Anti-endothelial αvβ3 antibodies are a major cause of intracranial bleeding in fetal-neonatal alloimmune thrombocytopenia

摘要

ObjectiveFetaleonatal alloimmune thrombocytopenia (FNAIT) is a severe bleeding disorder which can result in intracranial hemorrhage (ICH), leading to death or neurological sequelae. In Caucasians, maternal anti-HPA- 1a antibodies (abs) are responsible for the majority of cases. No predictive factors for ICH are available to guide prophylactic treatment during pregnancy. In this study, we investigated abs from mothers with ICH-positive FNAIT and with ICH-negative FNAIT in order to identify serological and functional differences between the groups.