Severity of clinical presentation in youth with type 1 diabetes is associated with differences in brain structure

摘要

ObjectiveDifferences in cognition and brain structure have been found in youth with type 1 diabetes compared to controls, even after relatively short disease duration. To determine whether severity of clinical presentation contributes to these differences, we obtained structural MRI scans in youth ages 7–17 who were either newly diagnosed with type 1 diabetes (<3.5 months from diagnosis, n=46) or a sibling without diabetes (n=28).