Association of polymorphisms in the regulatory region of the cyclophilin A gene (PPIA) with gene expression and HIV/AIDS disease progression

摘要

BackgroundHuman cyclophilin A (CypA) encoded by peptidyl prolyl isomerase A gene (PPIA), enhances human immunodeficiency virus type 1 (HIV-1) replication by aiding capsid uncoating. The association of genetic variation in the PPIA regulatory region with susceptibility to HIV-1 infection, disease progression and gene expression among black South Africans at risk for infection or infected with HIV-1 is unknown.