Prenatal airborne polycyclic aromatic hydrocarbon exposure LINE1 methylation and child development in a Chinese cohort

摘要

BackgroundPolycyclic aromatic hydrocarbons (PAH) are carcinogenic, neurotoxic environmental pollutants generated during incomplete combustion of fossil fuel and other organic material. PAH exposure has been associated with adverse fetal development and epigenetic alterations in cord blood. Several molecular epidemiology studies have established PAH-DNA adducts as biomarkers of PAH exposure.