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Hearing changes after intratympanically applied steroids for primary therapy of sudden hearing loss: a meta-analysis using mathematical simulations of drug delivery protocols

机译：鼓室内应用类固醇用于突发性听力损失的主要治疗后的听力变化：使用药物输送方案数学模拟的荟萃分析

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摘要

ObjectiveControlled and uncontrolled studies with primary intratympanic (IT) or combined intratympanic and systemic application of glucocorticosteroids for idiopathic sudden hearing loss (ISSHL) were analyzed by means of a meta-analysis in an attempt to establish optimal local drug delivery protocols.

机译：目的通过荟萃分析来分析原发性鼓膜内（IT）或鼓膜内和全身应用糖皮质激素治疗特发性突发性耳聋（ISSHL）的对照和非对照研究，以试图建立最佳的局部药物递送方案。

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期刊名称 other
作者
Arne Liebau; Olivia Pogorzelski; Alec N. Salt; Stefan K. Plontke;
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作者单位

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年(卷),期 -1(38),1
年度 -1
页码 19–30
总页数 25
原文格式 PDF
正文语种
中图分类
关键词
computer model intratympanic meta-analysis pharmacokinetics steroids sudden hearing loss;

机译：计算机模型;鼓室内;荟萃分析;药代动力学;类固醇;突然听力下降;

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专利

1. Hearing Changes After Intratympanic Steroids for Secondary (Salvage) Therapy of Sudden Hearing Loss: A Meta-Analysis Using Mathematical Simulations of Drug Delivery Protocols [J] . Liebau Arne, Pogorzelski Olivia, Salt Alec N., Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology . 2018,第7期

机译：突发听力损失的次级（抢购）治疗后尿酸尿液类固醇后的变化：使用药物递送方案的数学模拟的META分析
2. Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols. [J] . Salt AN, Gill RM, Plontke SK The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. . 2008,第10期

机译：听力变化对鼓膜内应用庆大霉素剂量的依赖性：使用临床药物递送方案的数学模拟进行的荟萃分析。
3. Comparison of Two Different Treatment Protocols Using Systemic and Intratympanic Steroids with and without Hyperbaric Oxygen Therapy in Patients with Severe to Profound Idiopathic Sudden Sensorineural Hearing Loss: A Randomized Controlled Trial [J] . Cho Ilyoung, Lee Hyun-Min, Choi Sung-Won, Audiology & neuro-otology . 2018,第4期

机译：患有患者严重患者患者的系统和尿酸尿液类固醇对两种不同治疗方案的比较严重致作性突如其术突如其来的感觉神经听力损失：随机对照试验
4. Comparison of school-based hearing screening protocols and the identification of noise induced hearing loss in adolescents [C] . Deanna K. Meinke, Noel Dice Congress of the International Commission on the Biological Effects of Noise . 2008

机译：基于学校的听力筛选方案的比较和青少年噪声引起噪声探测损失的识别
5. Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss [D] . Koide Yusuke, 小出悠介 2019

机译：解偶联蛋白2基因Ala55val多态性与突然的感音神经性听力丧失之间的关联。
6. Hearing changes after intratympanic steroids for secondary (salvage) therapy of sudden hearing loss: a meta-analysis using mathematical simulations of drug delivery protocols [O] . Arne Liebau, Olivia Pogorzelski, Alec N. Salt, -1

机译：鼓膜内类固醇用于突发性听力损失的二次（挽救）治疗后的听力变化：使用药物输送方案数学模拟的荟萃分析
7. Hearing Changes After Intratympanic Steroids for Secondary (Salvage) Therapy of Sudden Hearing Loss: A Meta-Analysis Using Mathematical Simulations of Drug Delivery Protocols [O] . Arne Liebau, Olivia Pogorzelski, Alec N. Salt, 2018

机译：尿性听力损失的次要（抢购）治疗后的听力变化：使用药物递送方案数学模拟的META分析

Hearing changes after intratympanically applied steroids for primary therapy of sudden hearing loss: a meta-analysis using mathematical simulations of drug delivery protocols

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