IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced

摘要

Aim of studyMutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) gene were recently discovered in vast majority of World Health Organization (WHO) grade II/III gliomas. This study is to understand the effects of IDH1 R132H mutation in gliomagenesis and to develop new strategies to treat glioma with IDH1 R132H mutation.