Five- and Six-Coordinated Silver(I) Complexes Derived from 26-(Pyridyl)iminodiadamantanes: Sustained Release of Bioactive Silver toward Bacterial Eradication

摘要

Silver(I) complexes of two designed tridentate ligands, namely, 2,6-(pyridyl)-iminoditriazaadamantane (pydTAm) and 2,6-(pyridyl)-iminodiadamantane (pydAm), have been synthesized and structurally characterized. [Ag(pydTAm)2](CF3SO3) (1), the hitherto unknown mer isomer of a silver(I) octahedral complex, crystallizes in a highly symmetric body-centered cubic I 43m space group. Quite in contrast, the Ag^I center in the analogous [Ag(pydAm)2](CF3SO3) (>2) complex resides in a trigonal-bipyramidal geometry and crystallizes in a triclinic P 1 space group with two crystallographically independent molecules in the asymmetric unit. Complex >1 exhibits exceptional solubility in aqueous media and leads to the efficient eradication of several bacterial strains upon sustained release of bioactive silver.