Aspirin Prevents NF-κB Activation and CDX2 Expression Stimulated by Acid and Bile Salts in Oesophageal Squamous Cells of Barretts Oesophagus Patients

摘要

ObjectiveIn previous studies using oesophageal squamous cells from patients with Barrett's oesophagus (NES-B cells) and from patients without Barrett's oesophagus (NES-G cells), we showed that acid and bile salts induced CDX2 expression only in NES-B cells. CDX2, a transcription factor required to form intestinal epithelium, is a target of NF-κB signaling, which can be inhibited by aspirin. We explored mechanisms underlying differences between NES-B and NES-G cells in CDX2 expression, and effects of aspirin on that CDX2 expression.