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A combination of routine blood analytes predicts fitness decrement in elderly endurance athletes

机译:常规血液分析物的组合可预测老年耐力运动员的体能下降

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摘要

Endurance sports are enjoying greater popularity, particularly among new target groups such as the elderly. Predictors of future physical capacities providing a basis for training adaptations are in high demand. We therefore aimed to estimate the future physical performance of elderly marathoners (runners/bicyclists) using a set of easily accessible standard laboratory parameters. To this end, 47 elderly marathon athletes underwent physical examinations including bicycle ergometry and a blood draw at baseline and after a three-year follow-up period. In order to compile a statistical model containing baseline laboratory results allowing prediction of follow-up ergometry performance, the cohort was subgrouped into a model training (n = 25) and a test sample (n = 22). The model containing significant predictors in univariate analysis (alanine aminotransferase, urea, folic acid, myeloperoxidase and total cholesterol) presented with high statistical significance and excellent goodness of fit (R2 = 0.789, ROC-AUC = 0.951±0.050) in the model training sample and was validated in the test sample (ROC-AUC = 0.786±0.098). Our results suggest that standard laboratory parameters could be particularly useful for predicting future physical capacity in elderly marathoners. It hence merits further research whether these conclusions can be translated to other disciplines or age groups.
机译:耐力运动正越来越受到人们的欢迎,特别是在老年人等新目标人群中。迫切需要对未来身体能力的预测,这些能力将为适应训练提供基础。因此,我们旨在使用一组易于访问的标准实验室参数来评估老年人马拉松运动员(跑步者/自行车手)的未来身体表现。为此,对47位老年马拉松运动员进行了身体检查,包括在基线和三年的随访期后进行的自行车测功和抽血检查。为了汇编包含基线实验室结果的统计模型,以预测后续的测功性能,该队列被分组为模型训练(n = 25)和测试样本(n = 22)。该模型在单变量分析中包含重要预测因子(丙氨酸氨基转移酶,尿素,叶酸,髓过氧化物酶和总胆固醇),具有很高的统计学意义和极好的拟合度(R 2 = 0.789,ROC-AUC = 0.951在模型训练样本中为±0.050),并在测试样本中得到了验证(ROC-AUC = 0.786±0.098)。我们的结果表明,标准的实验室参数对于预测老年马拉松运动员未来的身体能力尤其有用。因此,是否可以将这些结论转化为其他学科或年龄组值得进一步研究。

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