The C-2 derivatives of Salvinorin A ethoxymethyl ether Sal B and β-tetrahydropyran Sal B have anti-cocaine properties with minimal side effects

摘要

RationaleKappa-opioid receptor (KOPr) agonists have pre-clinical anti-cocaine and analgesic effects. However, side-effects including sedation, dysphoria, aversion, anxiety and depression limit their therapeutic development. The unique structure of Salvinorin A has been used to develop longer-acting KOPr agonists.