Inhaled Treprostinil Drug Delivery During Mechanical Ventilation and Spontaneous Breathing Using Two Different Nebulizers

摘要

ObjectiveTo determine the feasibility of delivering inhaled treprostinil during mechanical ventilation and spontaneous unassisted ventilation using the Tyvaso Inhalation System (TIS), and t Vibrating Mesh Nebulizer (VMN). We sought to compare differences in fine particle fraction (FPF), and absolute inhaled treprostinil mass delivered to neonatal, pediatric, and adult models affixed with a facemask, conventional, and high frequency ventilation between TIS and with different nebulizer locations between TIS and VMN.