Crosslinked shells for nano-assembled capsules: A new encapsulation method for smaller Gd3+-loaded capsules with exceedingly high relaxivities

摘要

Nano-assembled capsules can incorporate large payloads of high relaxivity Gd³⁺, permitting the development of highly detectable molecular imaging agents for MRI. A new encapsulating shell, based upon cross-linked peptides, is found to afford smaller capsules (127 nm average diameter) with exceptionally high per-Gd³⁺ relaxivities (70.7 s^-1mmolal^-1).