Stress-induced neuronal CSF1 provokes microglia-mediated neuronal remodeling and depressive-like behavior

摘要

Background:Chronic stress exposure causes neuronal atrophy and synaptic deficits in the medial prefrontal cortex (PFC), contributing to development of anxiety-and depressive-like behaviors. Concomitantly microglia in the PFC undergo morphological and functional changes following stress exposure, suggesting that microglia contribute to synaptic deficits underlying behavioral consequences.