Deletion of NF-κB/RelA in Angiotensin II-sensitive mesenchymal cells blocks aortic vascular inflammation and AAA formation

摘要

ObjectiveInfusion of angiotensin II (Ang II) induces extracellular matrix remodeling and inflammation resulting in abdominal aortic aneurysms (AAA) in normolipidemic mice. Although Ang II activates mesenchymal cells in the media and adventitia to become fibrogenic, the sentinel role of this mesenchymal population in modulating the inflammatory response and aneurysms is not known. We test the hypothesis that these ‘fibrogenic’ mesenchymal cells play a critical role in Ang II-induced aortic wall vascular inflammation and AAA formation.