Alterations in mRNA 3′UTR isoform abundance accompany gene expression changes in human Huntingtons disease brains

摘要

Romo et al. show the abundance of mRNA 3′UTR isoforms of huntingtin and a subset of other genes changes in Huntington's disease motor cortex. Genes with isoform alterations occur in pathways implicated in disease pathogenesis. Differential expression of RNA binding proteins may cause these isoform changes in Huntington's disease.